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Search over 300 published research articles on hypochlorous acid

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Results: 9 published articles

National Library of Medicine

Hypochlorous acid as a potential wound care agent: part I. Stabilized hypochlorous acid: a component of the inorganic armamentarium of innate immunity

Microbe(s): National Library of Medicine


Hypochlorous acid (HOCl), a major inorganic bactericidal compound of innate immunity, is effective against a broad range of microorganisms. Owing to its chemical nature, HOCl has never been used as a pharmaceutical drug for treating infection. In this article, we describe the chemical production, stabilization, and biological activity of a pharmaceutically useful formulation of...

NCBI - Oral Biofilm Bacteria

Effects of stabilized hypochlorous acid on oral biofilm bacteria

Microbe(s): NCBI - Oral Biofilm Bacteria


Low concentrations of HOCl (5 ppm), stabilized with 0.14% or 2% HAc, significantly reduced viability in multi-species biofilms representing supra- and sub-gingival oral communities, after 5 min, without causing erosion of HA surfaces. No equivalent antimicrobial effect was seen for CHX. Gram-positive and Gram-negative bacteria showed no significant differential suceptibility to stabilized...

NCBI - SARS-CoV-2-surrogate

Hypochlorous acid inactivates oral pathogens and a SARS-CoV-2-surrogate

Microbe(s): NCBI - SARS-CoV-2-surrogate


HOCl solution (45–60 ppm) is still effective against oral pathogens and SAR-CoV-2 surrogate viruses even in the presence of saliva and after passing through the dental unit water line. This study indicates that the HOCl solution can be used as therapeutic water or mouthwash and may ultimately reduce the risk of airborne infection in dental...

NCIB - Infectious Pathogens

The Effect of Hypochlorous Acid Disinfectant on the Reproduction of Details and Surface Hardness of Type III Dental Stone

Microbe(s): NCIB - Infectious Pathogens


A total of 100 samples of type III dental stone, 50 samples for each test, which include the reproduction of detail test and surface hardness test, were prepared and randomly divided into five groups, 10 samples for each test group, which include group A (control), group B (immersion in 200 ppm HOCl disinfectant for five minutes), group C (spraying with 200 ppm HOCl disinfectant for five...

BioMed Research International - Covid 19

Environmental Disinfection of a Dental Clinic during the Covid-19 Pandemic: A Narrative Insight

Microbe(s): BioMed Research International - Covid 19


Surface disinfection via aerosol (SDVA). The device produces dry fog through a turbine at high speed that atomized and sprays disinfectant. Usually, H2O2 and hypochlorous acid (HOCl) are used as a disinfectant (Figures 1 and 2). The disinfectant is atomized into ultrafine droplets, blown into the air, and, after 10-30 min, settles on all surfaces; these disinfectant droplets quickly begin to...

American Association of Oral and Maxillofacial Surgeons - COVID-19

COVID-19 (Coronavirus Disease 2019) Virus Structure and Mechanism of Infection

Microbe(s): American Association of Oral and Maxillofacial Surgeons - COVID-19


On contact with the virus, a disinfectant agent changes the protective protein coat, which loses its structure and aggregates, forming clumps of proteins with other viruses.9,10 Currently, the US Environmental Protection Agency has recommended numerous disinfectants against COVID-19 including hypochlorous acid (HOCl).11 The mechanism of disinfection involves the destroying of the cell wall of...

International Journal of Molecular Sciences - E. coli and P. gingivalis

Effectiveness of Hypochlorous Acid to Reduce the Biofilms on Titanium Alloy Surfaces in Vitro

Microbe(s): International Journal of Molecular Sciences - E. coli and P. gingivalis


Within the limitations of this in vitro model, HOCl is effective for cleaning biofilm-contaminated implant surfaces and has the potential to be an antiseptic for peri-implantitis treatment. These results suggest that the efficacy of HOCl is equivalent to NaOCl and CHX. The concentration of HOCl (0.018%) was lower than those for NaOCl (1.3%) and CHX (0.2%) but still showed efficacy against the...

Brazilian Dental Journal

Viability and Effects on Bacterial Proteins on Dental Oral Rinses with Hypochlorous Acid as Active Ingredient

Microbe(s): Brazilian Dental Journal


Hypochlorous acid rinses are proposed for plaque control and as a wound healing agent for its use in oral health, due to its low toxicity, high antimicrobial efficacy, anti-inflammatory effect, induction to cell proliferation and its background as a topical solution in the antisepsis of wounds in clinical medicine 16. HOCl has also the ability to oxidize the amino acid taurine and induce the...